How Clean Water Intake Can Increase Your Longevity
We all know that water is essential to our existence, but how often do you […]
By optimizing your hormone levels, you can live healthier for numerous decades
While most people think of testosterone as a male hormone, the reality is that both men and women benefit from maintaining balanced levels. First, test your baseline. Next, follow these biohacks to improve your performance, health, and even your lifespan.
Testosterone is an important hormone that plays a significant role in the overall health and longevity of both men and women. Although commonly associated with male sexual health, testosterone has far-reaching effects on many other areas, including muscle mass, bone density, cognition, mood, energy, and heart health.1 Unfortunately, testosterone levels naturally decline as we age, which can negatively impact our health.2
Both too little and too much testosterone have been linked to shorter lifespans. Testosterone promotes longevity by improving multiple aspects of heart health. Having optimal testosterone levels reduces the risk of heart disease by lowering cholesterol levels, improving insulin sensitivity, and reducing inflammation.1 Testosterone also helps maintain healthy blood vessels and prevent plaque from forming in them.3 Moreover, it helps preserve muscle mass, bone density, and fitness levels, all of which are linked to increased lifespan.4,5
Having optimal levels of testosterone is a good thing, however; having too much is a problem. High testosterone levels like those achieved by using large amounts of anabolic steroids, increase the risk of high blood pressure, heart disease, and early death.6
Testosterone Replacement Therapy (TRT) has emerged as a potential solution to address the natural decline of testosterone levels with age and promote longevity and overall well-being. The therapy involves administering testosterone via injections, pellets, patches, or gels to restore healthy levels in deficient men. One study demonstrated that older men with age-related low testosterone levels who received TRT lived longer and generally had better health outcomes.7
Hormone replacement therapy is not your only option for supporting your r testosterone levels. Other evidence-based ways to maintain healthy testosterone levels as you age include:
Biohacking your testosterone levels is critical for optimizing heart health, brain function, strength, muscle mass, and longevity. It’s important to test your levels and discuss the risks and benefits of any type of therapy with your doctor.
“The major effect of testosterone on the brain (of both males and females) is to make effort feel good.”
BodyLogicMD-affiliated physicians are renowned experts in natural bioidentical hormone replacement therapy, offering integrated fitness and nutrition programs to patients since 2003. With a track record of highly satisfied patients, you can trust that you’ll receive exceptional care when you visit a BodyLogicMD-affiliated physician. Your health and well-being are in capable hands.
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Plume: Your Virtual Home for Gender-Affirming Care. Plume understands the unique needs of transgender, nonbinary, and gender non-conforming individuals. Their services include hormone therapy and prescriptions for estrogen or testosterone. You can trust your Care Team to create a personalized care plan that respects your identity and prioritizes your well-being.
1. Daniel M Kelly, T Hugh Jones, Testosterone: a metabolic hormone in health and disease. Journal of Endocrinology, 2013;217(3):R25–45, doi: 10.1530/joe-12-0455, PMID: 23378050: https://pubmed.ncbi.nlm.nih.gov/23378050/.
2. B. R. Zirkin, J. L., Tenover. Aging and Declining Testosterone: Past, Present, and Hopes for the Future, Journal of Andrology, 2012;33(6):1111–8, doi: 10.2164/jandrol.112.017160, PMID: 22879528; PMCID: PMC4077344: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077344/.
3. Marcelo Rodrigues dos Santos, Shalender Bhasin, Benefits and Risks of Testosterone Treatment in Men with Age-Related Decline in Testosterone, Annual Review of Medicine, 2021;72(1):75–91, doi: 10.1146/annurev-med-050219-034711, PMID: 33217248: https://pubmed.ncbi.nlm.nih.gov/33217248/.
4. Preethi Srikanthan, Arun S. Karlamangla, Muscle Mass Index As a Predictor of Longevity in Older Adults, The American Journal of Medicine, 2014;127(6):547–53, doi: 10.1016/j.amjmed.2014.02.007, PMID: 24561114; PMCID: PMC4035379: https://pubmed.ncbi.nlm.nih.gov/24561114/.
5. Stephanie R. Dayer, et al., Does Superior Bone Health Promote a Longer Lifespan?, Geriatric Orthopaedic Surgery & Rehabilitation, 2021;12:215145932110362, doi: 10.1177/21514593211036231, PMID: 34395047; PMCID: PMC8358490: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358490/.
6. Miia Parssinen, Timo Seppala, Steroid Use and Long-Term Health Risks in Former Athletes, Sports Medicine, 2002;32(2):83–94, doi: 10.2165/00007256-200232020-00001, PMID: 11817994: https://pubmed.ncbi.nlm.nih.gov/11817994/.
7. F. Comhaire, Hormone replacement therapy and longevity, Andrologia, 2015;48(1):65–8, doi: 10.1111/and.12419, PMID: 25892327: https://pubmed.ncbi.nlm.nih.gov/25892327/.
8. David R. Hooper, et al., Endocrinological Roles for Testosterone in Resistance Exercise Responses and Adaptations, Sports Medicine, 2017;47(9):1709–20, doi: 10.1007/s40279-017-0698-y, PMID: 28224307: https://pubmed.ncbi.nlm.nih.gov/28224307/.
9. Joseph Whittaker, Kexin Wu, Low-fat diets and testosterone in men: Systematic review and meta-analysis of intervention studies, The Journal of Steroid Biochemistry and Molecular Biology, 2021;210:105878, doi: 10.1016/j.jsbmb.2021.105878, PMID: 33741447: https://pubmed.ncbi.nlm.nih.gov/33741447/.
10. Tung Wai Auyeung, et al., Sleep Duration and Disturbances Were Associated With Testosterone Level, Muscle Mass, and Muscle Strength—A Cross-Sectional Study in 1274 Older Men, Journal of the American Medical Directors Association, 2015;16(7):630.e1-630.e6, doi: 10.1016/j.jamda.2015.04.006, PMID: 25959075: https://pubmed.ncbi.nlm.nih.gov/25959075/.
11. Arcangelo Barbonetti, et al., Association between 25(OH)-vitamin D and testosterone levels: Evidence from men with chronic spinal cord injury, The Journal of Spinal Cord Medicine, 2015;39(3):246–52, doi: 10.1179/2045772315y.0000000050, PMID: 26312544; PMCID: PMC5073757: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073757/.
12. Heitor O. Santos, Filipe J. Teixeira, Use of medicinal doses of zinc as a safe and efficient coadjutant in the treatment of male hypogonadism, The Aging Male, 2019;23(5):669–78, doi: 10.1080/13685538.2019.1573220, PMID: 30767598: https://pubmed.ncbi.nlm.nih.gov/30767598/.
13. Vedat Cinar, et al., Effects of Magnesium Supplementation on Testosterone Levels of Athletes and Sedentary Subjects at Rest and after Exhaustion, Biological Trace Element Research, 2010;140(1):18–23, doi: 10.1007/s12011-010-8676-3, PMID: 20352370: https://pubmed.ncbi.nlm.nih.gov/20352370/.
14. Antonino Bianco, et al., Alcohol consumption and hormonal alterations related to muscle hypertrophy: a review, Nutrition & Metabolism, 2014;11(1), doi: 10.1186/1743-7075-11-26, PMID: 24932207; PMCID: PMC4056249: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056249/.
DHEA, which is short for dehydroepiandrosterone, has been shown to be a key hormone for healthy aging. Combined with biohacks like exercise and stress management, healthy DHEA levels can help you avoid disease and live longer.
Dehydroepiandrosterone (DHEA) is a hormone produced by the adrenal glands that serves as a building block for the major sex hormones in the body, including estrogen and testosterone. Beyond its role as a hormone precursor, DHEA also has anti-inflammatory effects and helps with brain health and immune function.1 Emerging research suggests that it may play a key role in aging and longevity. Like many other hormones, DHEA levels tend to fall as we age, with an average loss of 60% between the ages of 40 and 80.2 Low DHEA levels can increase the risk of type 2 diabetes, heart disease, stroke, colon cancer, and death. It’s therefore very important to maintain healthy levels as we age.3,4,5,6,7
A number of trials have studied the effects of DHEA supplementation on older adults. These trials have found that DHEA increases bone density and insulin sensitivity, helps with fat loss, and improves heart health, sexual function, mood, and well-being.8,9,10,11,12,13,14,15 DHEA applied as a cream also improves skin health and reduces signs of aging.16
Some evidence-based ways to maintain healthy DHEA levels as you age include:
You can also supplement with DHEA, one of the few hormones available over-the-counter. In any event, it’s important that you speak with your doctor before you begin supplementing. People with cancers involving sex hormones like prostate cancer and certain breast cancers should avoid taking DHEA.21
“By optimizing levels of DHEA, you can help support hormonal health.”
BIOLabs PRO Natural DHEA 20 Cream offers a bioidentical DHEA cream with 20MG of DHEA per pump. It’s a natural product that contains no harmful preservatives, features an easy-to-use pump, and provides a two-month supply or more.
Twist 25 DHEA cream contains pharmaceutical-grade bioidentical DHEA, a hormone produced by both men and women. Each pump delivers about 25 mg of DHEA. Research suggests maintaining optimal DHEA levels offers various health benefits.
Herb Pharm prepares its Ashwagandha glycerite from the roots of Certified Organic Withania somnifera plants. These roots are carefully harvested at their peak of readiness and undergo a shade-drying process to retain their full color and aroma. Subsequently, they are meticulously extracted. This herb holds a revered place in Ayurvedic traditions.
Moon Juice presents a clinical-strength blend of four potent adaptogens, rooted in Ayurveda and Chinese medicine, promoting energy, focus, and cortisol regulation. Daily use yields transformative results, with subscribers receiving eco-friendly pouches for refills.
Ashwagandha, often referred to as “Indian Ginseng,” is a prized herb in Ayurvedic Medicine. With a rich history of therapeutic use, it boasts a wide array of healing properties. These include enhancing the immune system, inspiring vitality, boosting Super Oxide Dismutase levels, harmonizing mind-body-spirit, and mitigating stress’s effects. Ashwagandha is a versatile herb renowned for promoting well-being.
Revolutionary and time-tested compounds packed into capsules for a jitter-free energy boost. Jumpstart your day and tackle tasks without coffee jitters. Focus Capsules combine potent nootropics, antioxidants, and herbs for enhanced focus, mood, and alertness. Elevate your morning coffee, power through workouts, or stay sharp during meetings with their proprietary blend.
1. Wiebke Arlt, Dehydroepiandrosterone and ageing, Best Practice & Research Clinical Endocrinology & Metabolism, 2004;18(3):363–80, doi: 10.1016/j.beem.2004.02.006, PMID: 15261843: https://pubmed.ncbi.nlm.nih.gov/15261843/.
2. A Bélanger, et al., Changes in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men, The Journal of Clinical Endocrinology & Metabolism, 1994;79(4):1086–90, doi: 10.1210/jcem.79.4.7962278, PMID: 7962278: https://pubmed.ncbi.nlm.nih.gov/7962278/.
3. Krzysztof Rutkowski, et al., Dehydroepiandrosterone (DHEA): Hypes and Hopes, Drugs, 2014;74(11):1195–207, doi: 10.1007/s40265-014-0259-8, PMID: 25022952: https://pubmed.ncbi.nlm.nih.gov/25022952/.
4. Adela Brahimaj, et al., Serum dehydroepiandrosterone levels are associated with lower risk of type 2 diabetes: the Rotterdam Study, Diabetologia, 2016;60(1):98–106, doi: 10.1007/s00125-016-4136-8, PMID: 27771738; PMCID: PMC6518366: https://pubmed.ncbi.nlm.nih.gov/27771738/.
5. Claes Ohlsson, et al., Low Serum Levels of Dehydroepiandrosterone Sulfate Predict All-Cause and Cardiovascular Mortality in Elderly Swedish Men, The Journal of Clinical Endocrinology & Metabolism, 2010;95(9):4406–14, doi: 10.1210/jc.2010-0760, PMID: 20610590: https://pubmed.ncbi.nlm.nih.gov/20610590/.
6. Monik C. Jiménez, et al., Low Dehydroepiandrosterone Sulfate is Associated With Increased Risk of Ischemic Stroke Among Women, Stroke, 2013;44(7):1784–9, doi: 10.1161/strokeaha.111.000485, PMID: 23704104; PMCID: PMC3811081: https://pubmed.ncbi.nlm.nih.gov/23704104/.
7. A J Alberg, et al., Serum dehydroepiandrosterone and dehydroepiandrosterone sulfate and the subsequent risk of developing colon cancer, Cancer Epidemiology, Biomarkers & Prevention, 2000;9(5):517-21, PMID: 10815698: https://pubmed.ncbi.nlm.nih.gov/10815698.
8. Catherine M. Jankowski, et al., Effects of Dehydroepiandrosterone Replacement Therapy on Bone Mineral Density in Older Adults: A Randomized, Controlled Trial, The Journal of Clinical Endocrinology & Metabolism, 2006;91(8):2986–93, doi: 10.1210/jc.2005-2484, PMID: 16735495: https://pubmed.ncbi.nlm.nih.gov/16735495/.
9. Giovanni Corona, et al., Dehydroepiandrosterone Supplementation in Elderly Men: A Meta-Analysis Study of Placebo-Controlled Trials, The Journal of Clinical Endocrinology & Metabolism, 2013;98(9):3615–26, doi: 10.1210/jc.2013-1358, PMID: 23824417: https://pubmed.ncbi.nlm.nih.gov/23824417/.
10. Hiroaki Kawano, et al., Dehydroepiandrosterone Supplementation Improves Endothelial Function and Insulin Sensitivity in Men, The Journal of Clinical Endocrinology & Metabolism, 2003;88(7):3190–5, doi: 10.1210/jc.2002-021603, PMID: 12843164: https://pubmed.ncbi.nlm.nih.gov/12843164/.
11. Dennis T. Villareal, John O.Holloszy, Wendy M. Kohrt, Effects of DHEA replacement on bone mineral density and body composition in elderly women and men, Clinical Endocrinology, 2000;53(5):561–8, doi: 10.1046/j.1365-2265.2000.01131.x, PMID: 11106916: https://pubmed.ncbi.nlm.nih.gov/11106916/.
12. A J Morales, et al., Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age, The Journal of Clinical Endocrinology & Metabolism, 1994;78(6):1360–7, doi: 10.1210/jcem.78.6.7515387, PMID: 7515387: https://pubmed.ncbi.nlm.nih.gov/7515387/.
13. Mary Panjari, Susan R. Davis, Vaginal DHEA to treat menopause related atrophy: A review of the evidence, Maturitas, 2011;70(1):22–5, doi: 10.1016/j.maturitas.2011.06.005, PMID: 21733647: https://pubmed.ncbi.nlm.nih.gov/21733647/.
14. Mary Panjari, Susan R. Davis, DHEA therapy for women: effect on sexual function and wellbeing, Human Reproduction Update, 2007;13(3):239–48, doi: 10.1093/humupd/dml055, PMID: 17208951: https://pubmed.ncbi.nlm.nih.gov/17208951/.
15. Clayton Peixoto, et al., The Effects of Dehydroepiandrosterone (DHEA) in the Treatment of Depression and Depressive Symptoms in Other Psychiatric and Medical Illnesses: A Systematic Review, Current Drug Targets, 2014;15(9):901–14, doi: 10.2174/1389450115666140717111116, PMID: 25039497: https://pubmed.ncbi.nlm.nih.gov/25039497/.
16. Stéphanie Nouveau, et al., Effects of topical DHEA on aging skin: A pilot study, Maturitas, 2008;59(2):174–81, doi: 10.1016/j.maturitas.2007.12.004, PMID: 18242894: https://pubmed.ncbi.nlm.nih.gov/18242894/.
17. Jennifer L. J. Heaney, Douglas Carroll, Anna C. Phillips, DHEA, DHEA-S and cortisol responses to acute exercise in older adults in relation to exercise training status and sex, AGE, 2011;35(2):395–405, doi: 10.1007/s11357-011-9345-y, PMID: 22105939; PMCID: PMC3592957: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592957/.
18. Anna-Karin Lennartsson, et al., Perceived Stress at Work Is Associated with Lower Levels of DHEA-S, PLoS ONE, 2013;8(8):e72460, doi: 10.1371/journal.pone.0072460, PMID: 24015247; PMCID: PMC3756071: https://pubmed.ncbi.nlm.nih.gov/24015247/.
19. Robert Garrison, Walter G Chambliss, Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial, Alternative Therapies in Health and Medicine, 2006;12(1):50-4, PMID: 16454147: https://pubmed.ncbi.nlm.nih.gov/16454147/.
20. Adrian L. Lopresti, Peter D. Drummond, Stephen J. Smith, A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha (Withania somnifera) in Aging, Overweight Males, American Journal of Men’s Health, 2019;13(2):155798831983598, doi: 10.1177/1557988319835985, PMID: 30854916; PMCID: PMC6438434: https://pubmed.ncbi.nlm.nih.gov/30854916/.
21. Shelley S. Tworoger, et al., The Association of Plasma DHEA and DHEA Sulfate with Breast Cancer Risk in Predominantly Premenopausal Women, Cancer Epidemiology, Biomarkers & Prevention, 2006;15(5):967–71, doi: 10.1158/1055-9965.epi-05-0976, PMID: 16702378: https://pubmed.ncbi.nlm.nih.gov/16702378/.
Do women live longer because they have more estrogen? This is one of the ideas that underscores the importance of this hormone for biohacking longevity. Create hormonal balance and improve your health with proven effective methods.
Estrogen is composed of three female sex hormones: estrone, estradiol, and estriol. Estradiol is the most potent estrogen and plays a key role in reproduction, fertility, and bone, heart, joint, brain, and skin health.1 It also plays an important role in longevity. In fact, one of the leading hypotheses as to why women live longer than men is that they have higher levels of estrogen. Indeed, estrogens may activate certain longevity genes that work to reduce inflammation and oxidative stress.2 Male mice given a weak form of estrogen saw up to a 20% increase in their lifespan.3 Moreover, female centenarians (100 years or older) are more likely to have higher levels of estrogen.4
Estrogen levels peak in a woman’s 20s and decrease by 50% by age 50, dropping sharply with menopause.5 This drop in estrogen can cause many unpleasant symptoms including poor sleep, depressed mood, fatigue, and joint pain.6
In men, estrogen levels decline at a much slower pace as they age, and the ratio of estrogen to testosterone levels increases.7 This decline in estrogen is mainly due to the decline in testosterone levels as most of the estrogen in men is converted from testosterone.7 Symptoms of estrogen imbalances in men include erectile dysfunction, increased breast tissue (gynecomastia), and fatigue.8
Unfortunately, it’s much harder for women to maintain healthy estrogen levels as they age than it is for men to maintain healthy testosterone levels. This is due to the fact that during menopause the ovaries–the main source of estrogen in women–stop producing estrogen.5 Thankfully, there are certain biohacks that can help.
The following biohacks may help women maintain healthy estrogen levels and/or control symptoms of low estrogen as they age:
If natural therapies fail you, Estrogen Replacement Therapy (ERT) is another solution for estrogen loss. It involves administering estrogen via injections, creams, patches, vaginal inserts, and pills. ERT has been shown to reduce symptoms of menopause, improve bone health, and reduce the risk of heart disease and death when provided soon after menopause.15 However, studies have demonstrated a slight increase in breast cancer risk with long-term ERT use.16
Men can typically improve their estrogen levels by increasing their testosterone levels. Some evidence-based ways to maintain healthy estrogen levels in men as they age include:
Both men and women can benefit from optimally maintaining their estrogen levels as they age. It’s important to test your levels and discuss the risks and benefits with your doctor before starting anything like Estrogen Replacement Therapy.
“When your hormones are in balance, neither too high nor too low, you look and feel your best.”
Integrative offers high-potency Vitamin D3, providing a convenient way to boost cholecalciferol intake at 125 mcg (5000 IU). This supports a robust immune system and promotes healthy bones. Extensive research underscores the role of increased cholecalciferol in enhancing calcium absorption, contributing significantly to overall bone health.
Terra Origin’s A-D-K Essential Vitamins, crafted with premium nutraceuticals, is a vegan, non-GMO daily supplement designed to fortify and maintain immune, heart, and bone health. This potent blend of Vitamins A, D, and K, encapsulated in MCT Oil, promotes cell production, aids in calcium absorption for bone density, and provides cardiovascular support.
Aura transforms mental wellness with personalized content. It offers a vast library of mindfulness resources for better well-being and sleep quality. Recognized in publications like The New York Times and Forbes, Aura’s 5-million strong user community enjoys its diverse expertise. Unlike generic self-care apps, Aura crafts a magical, tailored experience for each user, avoiding one-size-fits-all approaches.
Stardust, a free hormone health app, combines science, ancient wisdom, and AI to help users understand and sync with their menstrual cycle. It offers personalized insights, period predictions, mood tracking, and more. Founded and led by women, it ensures data privacy while fostering a deeper connection with one’s body.
Moody Month tailors daily wellness for women based on their menstrual cycles. Receive daily body forecasts and practical advice on mood, food, and fitness to optimize well-being. Expert insights from health specialists help you understand hormonal influences. Log your energy, mood, and stress levels, identify patterns, and access tailored content for fitness, mindfulness, and nutrition.
Headspace delivers everyday mindfulness and meditation through expert-led guided sessions, courses, and exercises. Suitable for all experience levels, it offers personalized recommendations tailored to your preferences. Whether you prefer short or long sessions, meditating with friends, or soothing content for improved sleep and focus, Headspace paves your way to daily mindfulness.
1. Seema Patel, et al., Estrogen: The necessary evil for human health, and ways to tame it, Biomedicine & Pharmacotherapy, 2018;102:403–11, doi: 10.1016/j.biopha.2018.03.078, PMID: 29573619: https://pubmed.ncbi.nlm.nih.gov/29573619/.
2. Jose Viña, et al., Why Females Live Longer Than Males: Control of Longevity by Sex Hormones, Science of Aging Knowledge Environment, 2005;2005(23):pe17, doi: 10.1126/sageke.2005.23.pe17, PMID: 15944465: https://pubmed.ncbi.nlm.nih.gov/15944465/.
3. David E. Harrison, et al., 17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex, Aging Cell, 2021;20(5):e13328, doi: 10.1111/acel.13328, PMID: 33788371; PMCID: PMC8135004: https://pubmed.ncbi.nlm.nih.gov/33788371/.
4. Shihui Fu, et al., Centenarian longevity had inverse relationships with nutritional status and abdominal obesity and positive relationships with sex hormones and bone turnover in the oldest females, Journal of Translational Medicine, 2021;19(1):436, doi: 10.1186/s12967-021-03115-7, PMID: 34663361; PMCID: PMC8522151: https://pubmed.ncbi.nlm.nih.gov/34663361/.
5. Edwin D. Lephart, A review of the role of estrogen in dermal aging and facial attractiveness in women, Journal of Cosmetic Dermatology, 2018;17(3):282–8, doi: 10.1111/jocd.12508, PMID: 29436770: https://pubmed.ncbi.nlm.nih.gov/29436770/.
6. Nanette Santoro, C. Neill Epperson, Sarah B. Mathews, Menopausal Symptoms and Their Management, Endocrinology and Metabolism Clinics of North America, 2015;44(3):497–515, doi: 10.1016/j.ecl.2015.05.001, PMID: 26316239; PMCID: PMC4890704: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890704/.
7. Orwoll Eric, et al., Testosterone and Estradiol among Older Men, The Journal of Clinical Endocrinology & Metabolism, 2006;91(4):1336–44, doi: 10.1210/jc.2005-1830, PMID: 16368750: https://pubmed.ncbi.nlm.nih.gov/16368750/.
8. Tong Chen, et al., Different levels of estradiol are correlated with sexual dysfunction in adult men, Scientific Report, 2020;10(1):12660, doi: 10.1038/s41598-020-69712-6, PMID: 32728148; PMCID: PMC7391660: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391660/.
9. Carolina Kimie Moriyama, et al., A randomized, placebo-controlled trial of the effects of physical exercises and estrogen therapy on health-related quality of life in postmenopausal women, Menopause, 2008;15(4):613–8, doi: 10.1097/gme.0b013e3181605494, PMID: 18551087: https://pubmed.ncbi.nlm.nih.gov/18551087/.
10. Jennifer L. Gordon, et al., Endocrine and psychosocial moderators of mindfulness-based stress reduction for the prevention of perimenopausal depressive symptoms: A randomized controlled trial, Psychoneuroendocrinology, 2021;130:105277, doi: 10.1016/j.psyneuen.2021.105277, PMID: 34058560: https://pubmed.ncbi.nlm.nih.gov/34058560/.
11. Soleymani Mahshid, et al., Dietary patterns and their association with menopausal symptoms: a cross-sectional study, Menopause, 2019;26(4):365–72, doi: 10.1097/gme.0000000000001245, PMID: 30363011: https://pubmed.ncbi.nlm.nih.gov/30363011/.
12. Masumeh Ghazanfarpour, et al., Effects of red clover on hot flash and circulating hormone concentrations in menopausal women: a systematic review and meta-analysis, Avicenna Journal of Phytomedicine, 2015;5(6):498–511, PMID: 26693407; PMCID: PMC4678495: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678495/.
13. Kristy K. Michael Miller, et al., DHEA metabolites activate estrogen receptors alpha and beta, Steroids, 2013;78(1):15–25, doi: 10.1016/j.steroids.2012.10.002, PMID: 23123738; PMCID: PMC3529809: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529809/.
14. Keiko Kinuta, et al., Vitamin D Is an Important Factor in Estrogen Biosynthesis of Both Female and Male Gonads, Endocrinology, 2000;141(4):1317–24, doi: 10.1210/endo.141.4.7403, PMID: 10746634: https://pubmed.ncbi.nlm.nih.gov/10746634/.
15. Roger A. Lobo, Hormone-replacement therapy: current thinking, Nature Reviews Endocrinology, 2016;13(4):220–31, doi: 10.1038/nrendo.2016.164, PMID: 27716751: https://pubmed.ncbi.nlm.nih.gov/27716751/.
16. Yana Vinogradova, Carol Coupland, Julia Hippisley-Cox, Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases, BMJ 2020:m3873, doi: 10.1136/bmj.m3873, PMID: 33115755; PMCID: PMC7592147: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592147/.
17. C. Lord, Z. Sekerovic, J. Carrier, Sleep regulation and sex hormones exposure in men and women across adulthood, Pathologie Biologie, 2014;62(5):302–10, doi: 10.1016/j.patbio.2014.07.005, PMID: 25218407: https://pubmed.ncbi.nlm.nih.gov/25218407/.
18. Paul G. Cohen, Obesity in men: The hypogonadal–estrogen receptor relationship and its effect on glucose homeostasis, Medical Hypotheses, 2008;70(2):358–60, doi: 10.1016/j.mehy.2007.05.020, PMID: 17825496: https://pubmed.ncbi.nlm.nih.gov/17825496/.
19. Ruba Riachy, Kevin McKinney, Demidmaa R. Tuvdendorj, Various Factors May Modulate the Effect of Exercise on Testosterone Levels in Men, Journal of Functional Morphology and Kinesiology, 2020;5(4):81, doi: 10.3390/jfmk5040081, PMID: 33467296; PMCID: PMC7739287: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7739287/.
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Max Gotzler, also known as the “Lifestyle Biohacker,” is a Berlin-based author, coach, and entrepreneur who leads the largest German biohacking community. His focus is on lifestyle strategies that can enhance energy and well-being while reducing stress.
Formerly a professional athlete, Max discovered the power of the Flow State in achieving a healthy lifestyle and optimal well-being. He founded Flowgrade, a lifestyle company offering biohacking courses and products that help people achieve the Flow State, reach peak performance, and essentially live their best life.
Max is the host of The Flowgrade Show and regularly encourages his Instagram followers to proactively optimize their health. He’s a regular speaker at biohacking summits and a well-received guest on popular podcasts, where he shares his knowledge on personal development and biohacking for healthier lifestyles. His expertise has been featured in various media outlets including ZEIT Online, Brand Eins, ARD, ZDF, and Bloomberg.
Dr. Olli Sovijarvi, a Finnish medical doctor, biohacker, and best-selling author, is known for his preventive and holistic approach to health. With a background in the Finnish Medical Service, he now offers personalized coaching and biohacking training for physical and mental performance optimization. His techniques are popular with athletes and CEOs seeking a balanced and energized lifestyle.
Dr. Sovijarvi is a co-founder of the Biohacker Center, which provides evidence-based information, biomarker tests, and products for biohacking and optimum health performance. He is a sought-after speaker at Biohacking conferences, has a committed Instagram audience, has been featured in Men’s Health and other media outlets, and is a frequent guest on podcasts and Youtube.
Dr. Sovijarvi’s unique approach to nutrition, fitness, and performance optimization has helped countless individuals maximize their health and well-being. Through his coaching and training programs, he continues to empower people to take control of their health and reach their full potential.
Unveiling the power of hormones for a balanced and enduring life.
Optimizing testosterone levels can have a significant impact on longevity. Testosterone plays a crucial role in maintaining muscle mass, bone density, cognitive function, and overall vitality. By addressing hormonal imbalances and ensuring optimal testosterone levels, individuals can support longevity, enhance physical performance, and maintain a healthy hormonal profile.
Biohackers see the importance of testosterone optimization for longevity. He emphasizes the need to address hormonal imbalances through lifestyle modifications, stress reduction, exercise, and potentially targeted supplementation when necessary. Optimizing testosterone levels can positively influence overall well-being and longevity.
DHEA (Dehydroepiandrosterone) is a precursor hormone that plays a role in the production of other hormones, including testosterone and estrogen. Supplementing with DHEA may support hormone balance, improve energy levels, and promote overall well-being. By addressing DHEA levels through supplementation when needed, individuals can potentially biohack longevity.
Yes, optimizing estrogen levels is crucial for both men and women in the pursuit of longevity. Balanced estrogen levels support bone health, cardiovascular function, and cognitive function. By addressing estrogen imbalances through lifestyle adjustments, targeted supplementation, or hormonal therapies, individuals can potentially enhance longevity and overall well-being.
Hormone balance is a key aspect of biohacking longevity. Hormones, such as testosterone, estrogen, and DHEA, influence various physiological processes and overall health. By optimizing hormone levels through lifestyle modifications, stress management, and potentially targeted interventions, individuals can support longevity and enhance overall well-being.
Yes, lifestyle modifications play a significant role in biohacking longevity with hormones. Factors such as exercise, stress reduction techniques, quality sleep, and a balanced diet can positively impact hormone balance. By adopting a comprehensive approach that includes healthy lifestyle choices, individuals can optimize hormone levels and support longevity.
Biohacking strategies to naturally support hormone balance include maintaining a healthy weight, engaging in regular exercise, managing stress levels, getting quality sleep, and consuming a nutrient-dense diet. These strategies can contribute to hormonal equilibrium and enhance longevity and overall well-being.
Yes, targeted supplementation can be a part of biohacking longevity with hormones. For example, specific nutrients like zinc, magnesium, and vitamin D may support testosterone production. However, it is essential to consult with a healthcare professional or hormone specialist to determine individual needs and ensure safe and effective supplementation.
Chronic stress can disrupt hormone balance, leading to negative health effects and potentially reducing longevity. Effective stress management techniques, such as meditation, mindfulness, and engaging in stress-reducing activities, help regulate cortisol (the stress hormone) and promote overall hormonal equilibrium, thereby supporting longevity.
Yes, regular hormone testing is an essential component of biohacking longevity. Monitoring hormone levels through blood or saliva tests allows individuals to assess their hormonal status, identify imbalances, and make informed decisions regarding lifestyle modifications, supplementation, or targeted interventions to optimize hormone balance and support longevity.
Discover the critical role of hormones in the aging process and explore biohacks to optimize hormone levels for a longer, healthier life.
Discover podcasts, YouTube channels, websites, apps, and more to enhance your knowledge and empower your biohacking journey.
The Peter Attia Drive Podcast, hosted by Dr. Peter Attia, explores the intersections of health, longevity, and performance.
With a focus on optimizing human potential, Dr. Attia engages in deep conversations with leading experts across various fields. Through these discussions, the podcast delves into biohacking strategies, cutting-edge research, and evidence-based practices for improving health and well-being.
Dr. Attia’s inquisitive approach and commitment to scientific rigor create a platform where biohacking techniques and innovations are explored. The podcast offers listeners valuable insights and practical tools to enhance their physical and mental performance, promoting a biohacking mindset for achieving optimal health and longevity.
Bryan Johnson’s YouTube channel showcases his remarkable journey and Project Blueprint, which aims to achieve optimal metabolic health and longevity.
As the world’s most measured human, Johnson freely shares his protocols and data, detailing his achievement of metabolic health equivalent to the top 1.5% of 18-year-olds, 66% lower inflammation compared to the average 10-year-old, and a reduction in his speed of aging by 31 years.
He is the founder of Kernel, responsible for the world’s first mainstream non-invasive neuroimaging system, and OS Fund, where he invested $100 million in engineering atoms, molecules, and organisms. Johnson’s channel inspires with his pursuit of personal and global well-being through self-improvement and collective cooperation.